Shyng, Show-Ling ^{Individualisierte Person Person}

We are interested in understanding ion channel regulation in health and disease. Specifically, our research focuses on ATP-sensitive K+ (KATP) channels, which link cell metabolism to membrane excitability and have important physiological functions including regulation of hormone secretion, protection of the heart and the brain against ischemic injuries, and control of vascular tone. Genetic variations in the KATP channel genes have been linked to several human diseases including congenital hyperinsulinism,neonatal diabetes, DEND (Developmental delay, Epilepsy, and Neonatal Diabetes) syndrome, dilated cardiomyopathy, and Cantu syndrome. Our efforts are directed towards understanding the structural and molecular basis of KATP channel biogenesis, trafficking, and gating, and how mutations in the channel genes disrupt channel biology to cause diseases. The ultimate goal is to translate basic science findings to disease treatment by developing mechanism-based therapeutic strategies.